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KMID : 0366219840190010039
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Korean Journal of Hematology
1984 Volume.19 No. 1 p.39 ~ p.44
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The Effect of 4'- (9-Acridinylamino) Methanesulfon-m-Anisidide (AMSA.) in the Treatment of Refractory Adult Acute Myeloid Leukemia
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서재열/J T Suh
최명규/승기배/박종원/김춘추/김동집/GaleR.P/M G Choi/K B Seung/C W Park/C C Kim/D J Kim/R P Gale
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Abstract
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Recent advances in the treatment of acute myeloid leukemia have led to higher
remission rates and to a quite increment in the remission duration and the survival. But
in those who are refractory to conventional regimens, the management was difficult.
There have been many reports that AMSA has a significant antileukemic activity,
especially in refractory cases. Twenty adults with refractory or relapsing acute myeloid
leukemia were put on AMSA with a total dose of 120 to 600mg/㎡ of BSA given over
1 to 5 days intravenously. Of twelve patients who received an adequate trial, two
achieved a complete remission and two had a partial remission, and it occurred when
AMSA was administered at a dose level of 120 mg/㎡/day for consecutive 5 days. Our
results suggest that AMSA seems to be not so effective as reported before, but it
should to considered to use as a part of new combination regimen.
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KEYWORD
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